Aloe polymannans and why Aloe Works!

It could be said that it works because the Aloe Vera plant produces at least 6 antiseptic agents: Lupeol, salicylic acid, urea nitrogen, cinnamonic acid, phenols, and sulphur. All of these substances are recognized as antiseptics because they kill or control mold, bacteria, fungus, and viruses, explaining why the plant has the ability to eliminate many internal and external infections. The Lupeol and salicylic acid in the juice explains why it is a very effective pain-killer.

Next, it could be said that Aloe Vera contains at least three anti-inflammatory fatty acids, cholesterol, campersterol and B-sitosterol (plant sterols) which explains why it is a highly effective treatment for burns, cuts, scrapes, abrasions, allergic reactions, rheumatoid arthritis, rheumatic fever, acid indigestion, ulcers, plus many inflammatory conditions of the digestive system and other internal organs, including the stomach, small intestine, colon, liver, kidney, and pancreas. B-sitosterol is also a powerful anti-cholestromatic which helps to lower harmful cholesterol levels, helping to explain its many benefits for heart patents.

If we add that Aloe contains at least 23 polypeptids (immune stimulators), then we understand why Aloe juice helps control a broad spectrum of immune system diseases and disorders, including HIV and AIDS. The polypeptids, plus the anti-tumor agents Aloe emodin and Aloe lectins, explains its ability to control cancer.
Aloe polymannans are complex sugars consisting of two mannose molecules and one glucose molecule. These polymannans are composed of different molecular lengths, weights, and sizes. Lengths vary from short, medium, large, and very large. Within these parameters, each size molecule performs it own unique function in the body.  Unlike other plants, Aloe Vera contains all FOUR chain lengths, instead of three. Again, the presence of the fourth (Acemannan Fraction, with its very large chain length) makes all the difference.
Once polymannans were detected in Aloe Vera, researchers noted that the varying chain length sizes of polymannans produce different healing properties.

For example:
Short Chain Length
Small Molecular Weight:  Reduces inflammation, provides digestive support, and balances blood sugar regulation.
Medium Chain Length
Medium Molecular Weight: Very effective intracellular antioxidants and free radical scavengers.  

Large Chain Length
Large Molecular Weight:  Has a direct anti-bacterial, antifungal, anti-parasitic and anti-viral effect.

Very Large Chain Length 
Very Large Molecular weight:  The very large molecules [also referred to as acemannans or Acemannan Fraction ] are immune modulating. They orchestrate a cascade of immune responses resulting in an enhanced activation of general host defense, tissue remodeling and healing for up regulation under active and down regulation over active immune systems.

Imagine a pearl necklace. The heavier, longer in length, and larger the pearls, the more valuable the necklace.  Imagine now that these pearls are actually individual mannans. The heavier and longer the chain of polymannans, the more vital and valuable the function performed in the body. In short, there are 4 chain lengths: short, medium, large, and very large. The very large chain length, with the heaviest molecular weight, is referred to as the Acemannan Fraction. It is these very large molecules that cause the body to produce a natural chemical, tumor necrosis factors, that shuts off blood supply to tumors.

In the 1990's, scientists discovered 200 sugar molecules found in nature. Of these 200 sugar molecules, the body requires 8 key sugars that support cell to cell communication. These 8 key sugars help the body properly synthesize bioactive molecules required in protein regulation. In fact, 7 of the 8 key sugars are found in the Aloe Vera inner gel; of these sugars, the most important or the "master" sugar is the polymannans (mannose).  Why? Because the body's receptor sites are waiting for this particular molecule, the mannose molecule, to dock there in order to start biological processes. The real importance of this "docking"  is for immune recognition; that is, recognising that which is self or other, that which is friendly or invasive (for example, viruses, parasites, etc.)  It is the only sugar found in nature that is not broken down by any enzyme. Furthermore, mannose is totally engulfed into the cell through a process known as endocytosis. Mannose is guided to very primitive receptor sites on each and every cell-from a hepatic cell to a brain cell. These sites, exclusive to mannose, are called MP6 (mannose phosphate 6).  

What are Aloe Polymannans?
Aloe polymannans are complex sugars consisting of two mannose molecules and one-glucose molecule.  When connected together, they are known as mannose, a polymannose beta 1, 4 molecules.  These polymannans are composed of many lengths, weights, and sizes. Lengths vary from short, medium, long to very long. Within these parameters, each size molecule performs it own unique function in the body.

Aloe’s Molecules & Characteristics
Aloe vera has a wide range in the size of the polysaccharide molecules. The Aloe Polysaccharides are composed of individual mannose and glucose sugar molecules connected together. The different size molecules are measured by how long is the molecule length and molecular weight is and the measurement is rated by daltons. These very large molecules referred to the “Acemannan” fraction of aloe polymannans. Acemannan is a trade name adopted by the United States Accepted Name Council.  
The varying sizes determine healing properties:

Short Chain Length
Small Molecular Weight:  Reduces inflammation - which is involved in such diseases as ulcerative colitis, arthritis, and gastric reflux. Also helps with the reduction of blood sugar with both type I and II diabetes.

Medium Chain Length
Medium Molecular Weight: Where as vitamins and minerals can only function outside the cells, polysaccharides are very effective intracellular antioxidants and free radical scavengers - very important in preventing and treating arteriosclerosis, heart disease and Parkinson’s disease. With the ever increasing pollution on the planet and loss of nutrients in the soil, the increase in free radicals and loss of cellular oxygen will only become worse with time. This makes Aloe vera polysaccharides even more important than ever.

Large Chain Length
Large Molecular Weight:  Has a direct anti-bacterial and anti-viral effect. Important with all the new infectious diseases cropping up and the older ones becoming more virulent from long term use of antibiotics.

Very Large Chain Length
Very Large Molecular weight:  The very large molecules are immune modulating, which have a powerful healing effect on AIDS, cancer and many different immune system disorders. It is also this large molecule that causes the body to produce a natural chemical, tumor necrosis factors, which functions to shut off the blood supply to tumors. (Dr. Ivan Danhof, M.D., Ph.D.)

Think of mannans as the pearls of a pearl necklace, ranging from lightweight short necklaces with small perils to very long heavy weight strand with large perils. Therefore, the heavier, longer in length, and larger the perils are, the more valuable the necklace becomes.  As with mannans, the heavier and longer the chain of polymannose, the more vital and valuable the function it performs within the body.

What Does Long Chain Aloe Polymannans Do in the Body?
Science now supports the concept that the very long chain mannans have specific immune functions in the body. The Immune system is the master system of the body.  Every other system relies on a properly functioning Immune system in order to optimally function themselves.  To illustrate how polymannans and the Immune system function together to support the rest of the body’s physiology, lets take a field trip to a concert hall where a full piece orchestra is performing...

Imagine each section of the orchestra (Woodwinds, Brass, Strings, and Percussion) as a system of the body (Digestive, Cardio Vascular, Endocrine, and Reproductive); the conductor is the master Immune system; and the sheet music plays the role of polymannose.  What would happen if there was only one set of sheet music for each section of the orchestra?  Only 2 or 3 musicians would actually be able to play, the rest of the musicians would either be off key, off tempo, or not even be able to play along.  Without mannose, systems would function irregularly if at all.  Now imagine the same scenario yet this time takes the sheet music away from the conductor!  The conductor would not be able to tell what part of the piece is being played, nor would he be able to anticipate what comes next.  What ever remaining functional musicians of the orchestra would soon become lost and cease to play because their leader is no longer able to perform his job.  Translation: TOTAL CHAOS.  Without mannose the Immune system would not be able to interpret the needs and concerns of the rest of the body and disease would set in rapidly, resulting in chronic, acute, debilitating diseases.

Just as a conductor needs sheet music to know what tempo and piece of music each section is playing in order to keep the orchestra in sync, so is true with the Immune system.  Polymannans are precursor signals, which alert the Immune system to the specific needs of individual systems, organs, tissues, and cells of the entire body.  

Every cell in the body is blind with out the presence of polymannose.  When mannose binds to the mannose phosphate 6 receptor site (found on every cell’s plasma membrane) a series of biological reactions occur.  First the cell becomes aware of its environment, inside and out.  The cell now has the ability to be on the alert to invaders, mutants, and allies’ discernment between the good guys and their foes. If the cell’s environment is compromised in ant way i.e. aberrant cell growth (cancer), fungal infection (candida albicans), bacterial infections (streptococcus), the cell is now able to release chemical signals into the blood stream to alert the immune system that it has a job to perform. When the individual leukocytes of the immune system (macrophage, lymphocytes, cytokines, killer T cells, B cells, NK cells etc.) have mannose docked to their cell membranes, the recognition, and defense process is calibrated properly, like the timing of a symphony: on key, on queue and with grace.

Polymannans are disappearing from our diet.
Aloe polymannans are not as readily available in our diet as they were even half a century ago. As the industrial age come to an end, the technological age began ushering in faster and cheaper agricultural practices at the expense of our soil and produce.  Grains, fruits, and vegetables grown today yield less and less nutrients with every new crop generation.  Also, with the practice of food processing and its growing popularity in the Standard American Diet due to its convenience and cost effectiveness, we are now faced with the question, “Have we become the victim of our own success?” The answer to this question is an astounding YES!

To simplify this matter lets only focus on our food supply.  We should be receiving polymannose through the consumption of wheat and rice.  In the last 50 years hybrid seeds were developed to strengthen crop resistance to fungus and other parasites, insects, pests, drought, heat and the many other perils of farming.  This was a cost effective move, however we sacrificed the most important value of the product: nutrition.  To make matters worse, poor farming practices such as synthetic fertilizers and pesticides further derogated our seeds nutrient value. Even if these products are organic, the amount necessary to eat would not meet the Immune system’s mannose requirement. Is it any wonder why our Immune related diseases are on the rise in epidemic proportions?  Through the nutritional supplementation of polymannose, there is hope.

In addition to polymannans, Aloe Vera provides some 200 bio-active and bio-available nutrients. Other chemical components of the inner gel includes yet not limited to:

Saccharides: Cellulose, Glucose, Mannose (Acemannan), L-rhamnose, Aldophentose, Xylose, Fructose, Glycoproteins, and Glycolipids.

Vitamins:  B1, B2, B6, B12, vitamin C, Choline, Folic acid, Vitamin E (alpha-tocopherol), and Vitamin A (beta carotene).

Minerals:  Calcium, Copper, Iron, Zinc, Magnesium (lactate), Phosphorus, Sodium, Zinc, Potassium, Manganese, and Chromium.

Essential Amino Acids:  Lysine, Threonine, Valine, Methinine, Leucine Isoleucine, and Pheylalanine. (7 out 8 essential)

Nonessential Amino Acids:  Histidine, Arginine, Hydroxyproline, Aspartic Acid, Glutamic Acid, Praline, Glycerine, Alanine, Isoleucine, Methionine, Serine,  Tyrosine,  and Tyrosine. (20 out 22 Amino Acids)

Enzymes:  Brady kinase, Amylase, Lipase, Catalase, Creatine, Oxidase, and Alkaline phosphatase.

Miscellaneous:  Pectin’s, Cholesterol, Triglycerides, Steroids, Beta-sitosterol, Lignins, Uric acid Gibberellin, Lectin-like substance, and Salicylic acid.

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